Nos Precursors and Satellite Cells

NO is a potent vasodilator which means that it causes blood vessels to open up allowing more blood to pass through. This results in increased blood being delivered to your muscles resulting in swelling of the muscles known as “The Pump”. This swelling not only looks impressive but also results in the same kind of stretching as Creatine, resulting in increased protein synthesis. Also, the increased blood flow means more oxygen and more nutrients flowing into muscles where they can be used to provide energy and support hypertrophy while more toxins and waste products are removed from the muscles.

Citrulline can be made from arginine as explained above, but it is also possible to make arginine from citrulline. Therefore, increasing citrulline creates an additional pool of arginine for the body to use as a precursor to NO (Nitric Oxide).

Everyone has heard about Nitric Oxide precursors and their effects on vasodilatation (opening of the veins and arteries to increase blood flow), but you may not have heard about how NO precursors like Arginine and its various forms along with things like Citrulline Malate and other potentiators of NO can greatly increase the chances of muscle cell differentiation.

Nitric Oxide is produced in the bloodstream as a mechanism of dilating blood vessels, but in the cell it is used to increase the transformation of satellite cells into mature muscle cells, this further increasing your ability to transform your genetic potential. Arginine is an amino acid that is often bound to a carrier or delivery molecule like malic acid, alpha-keto-glutarate or orotic acid to increase its potency and bioavailability. L-Citrulline is an amino acid that will further increase blood levels of Arginine and further increase your ability to make new muscle cells just waiting to be filled with protein.

The other interesting thing about NO is that it is released by muscles during a workout to help pump more blood into your working muscles. Using a combination of topical and systemic (full body) Arginine-AKG products can vastly increase the amount of NO released in your muscle tissue. That’s why Arginine products have such a great reputation among bodybuilders for increasing size and vascularity. Another big benefit is that Arginine helps burn stored body fat by up regulating the use of fats for fuel. So Arginine has a double benefit of increasing size and strength while cutting fat.

NITROS™, from LG Sciences has both Arginine-AKG and Citrulline Malate along with a host of other NO boosting agents. It’s the most advanced product on the market today and makes for a great part of your genetic stack to boost NO and build muscle using a systemic (full body) approach.

There is another way to deliver NO boosting nutrient where they are needed most that is topically through the use of Arginine. You might have a hard time believing this, but topical products deliver nutrients better in some cases than oral products and increase the amount of NO in a specific muscle group. There are quite a few products on the market, but my favorite is obviously NO INFUSE™ by LG Sciences.

NO INFUSE™ is the best topical product I have ever used. It makes my veins explode and warms me up before every workout. The other products I have tried literally burn your skin with painful ingredients. I had to wash off one of the products because it stung so badly. It has been suggested that one could use a similar product to increase blood flow to the penis. However, it hurt so bad on my arms that I wouldn’t be using it anywhere close to my manhood. NO INFUSE™ doesn’t have this issue, as it is completely painless and about the only side effect I noticed is a slight drying of my skin, which I remedied by using lotion later in the day. NO INFUSE™ can also boost the satellite expression directly into your trouble areas by targeting NO release where you need it most.

Infuse is specially formulated to penetrate the skin deep into the tissue with its amazing delivery system. Once through the skin, the unique NO releasing array of ingredients goes directly to your muscles to stimulate nitric oxide production resulting in improved blood flow, mind-blowing muscle pumps and satellite expression.

An issue with NO products is that you shouldn’t take them with high doses of caffeine and other stimulants that can naturally constrict the blood vessels, since you will be countering all of the benefits that NO production can bring. Also, take the Arginine oral products on an empty stomach and use the topical Arginine as a pre-workout warm up rub and then once again after the workout to keep the blood flowing to your freshly pumped muscles.

Below is an abstract showing Arginine and NO increasing satellite cell proliferation and expression. There are others that show how Arginine decreases fat, and this should help you see how you can gain valuable synergy when stacking items in this book. It’s really amazing that we have so many good products on the market to help you reach your goal of genetic transformation.

Systemic administration of L-arginine benefits mdx skeletal muscle function.

Barton ER, Morris L, Kawana M, Bish LT, Toursel T.

Department of Anatomy and Cell Biology, School of Dental Medicine, 441 Levy Building, 240 South 40th Street, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. erbarton@biochem.dental.upenn.edu

A major consequence of muscular dystrophy is that increased membrane fragility leads to high calcium influx and results in muscle degeneration and myonecrosis. Prior reports have demonstrated that increased nitric oxide production via L-arginine treatment of normal and mdx mice resulted in increased expression of utrophin and increased activation of muscle satellite cells, which could ameliorate the dystrophic pathology. We delivered L-arginine to normal and mdx mice, and examined muscles for any functional changes associated with its administration. Treated mdx muscles were less susceptible to contraction-induced damage and exhibited a rightward shift of the force-frequency relationship. Immunoblotting revealed increases in utrophin and gamma-sarcoglycan in the treated muscles. There was also a decrease in Evans blue dye uptake, indicating a reduction in myonecrosis. However, there was no decrease in serum creatine kinase or the proportion of central nuclei, nor any improvement in specific force. Together, these results show that L-arginine treatment can be beneficial to mdx muscle function, perhaps through a combination of enhanced calcium handling and increased utrophin, thereby decreasing muscle degeneration.

About the Author

Eric D. Marchewitz, is one of the leading supplement experts in the country, his articles online are taken from his best selling book ” Supplements For Genetic Growth ” which explains how you can increase the number of muscle cells in your body using supplement stacks available at any health food store. This book will demonstrate how the body will try and resist your efforts to grow insane muscles and how, as you age, the ability to create new muscle cells decline so make those cells now! The book is backed by science! This is the most amazing break through in supplement history! The book is available from the LG Sciences website www.lgsciences.com

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